Welcome to the Hargreaves lab

Research

Our lab is interested in epigenetic regulation mediated by the SWI/SNF chromatin remodeling complex. Chromatin remodeling complexes are known to create DNA accessibility through hydrolysis of ATP to allow binding of transcription and repair factors to DNA. However, these large multi-subunit complexes also contain many other proteins of unknown function that are critical for development and highly mutated in human disease. Our goal is to use a combination of biochemical and epigenomic assays to understand the mechanistic basis for diseases caused by these mutations. We are focusing on the related subunits ARID1A and ARID1B, which are mutated in cancer and neurodevelopmental disorders, respectively.