Hargreaves Lab

Our lab is interested in epigenetic regulation mediated by the BAF chromatin remodeling complex. Chromatin remodeling complexes are known to create DNA accessibility through hydrolysis of ATP to allow binding of transcription and repair factors to DNA. However, these large multi-subunit complexes also contain many other proteins of unknown function that are critical for development and highly mutated in human disease. Our goal is to use a combination of biochemical and epigenomic assays to understand the function of these complexes during normal cellular differentiation and the mechanistic basis for diseases caused by mutations in BAF complex subunits. We are focusing on cellular models of inflammation, cancer, and pluripotency.