all Publications

Maxwell, M.B., Hom-Tedla, M.S., Yi, J., Li, S., Rivera, S.A., Yu, J., Burns, M.J., McRae, H.M., Stevenson, B.T., Coakley, K.E., Ho, J., Gastelum, K.B., Bell, J.C., Jones, A.C., Eskander, R.N., Dykhuizen, E.C., Shadel, G.S., Kaech, S.M., Hargreaves, D.C. ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity. (2024) Cell. DOI: 10.1016/j.cell.2024.04.025

Wu, Z., Pope, S.D., Ahmed, N.S., Leung, D.L., Hajjar, S., Yue, Q., Anand, D.M., Kopp, E.B., Okin, D., Ma, W., Kagan, J.C., Hargreaves, D.C., Medzhitov, R., Zhou, X. Control of Inflammatory Response by Tissue Microenvironment. (2024) bioRxiv. DOI: 10.1101/2024.05.10.592432

Liao, J., Ho, J., Burns, M., Dykhuizen, E.C., Hargreaves, D.C. Collaboration between distinct SWI/SNF chromatin remodeling complexes directs enhancer selection and activation of macrophage inflammatory genes. (2024) Immunity. DOI: 10.1016/j.immuni.2024.05.008

Liao, J., Hargreaves, D.C. Coordination of transcription factors and SWI-SNF complexes regulates chromatin priming in developing T cells. (2024) Nature Immunology. DOI: 10.1038/s41590-024-01822-z

Chick, B.Y., Hargreaves, D.C. RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling. (2023) Nature Genetics. DOI: 10.1038/s41588-023-01628-z

McDonald, B., Chick, B.Y., Hargreaves, D.C., Kaech, S.M. Early Chromatin Remodeling Events in Acutely Stimulated CD8 T Cells. (2023) Yale J Biol Med. 96(4):467-473. DOI: 10.59249/AXGU7370

Mangalhara, K.C., Varanasi, S.K., Johnson, M.A., Burns, M.J., Rojas, G.R., Esparza Moltó, P.B., Sainz, A.G., Tadepalle, N., Abbott, K.L., Mendiratta, G., Chen, D., Farsakoglu, Y., Kunchok, T., Hoffmann, F.A., Parisi, B., Rincon, M., Vander Heiden, M.G., Bosenberg, M., Hargreaves, D.C., Kaech, S.M., Shadel, G.S. Manipulating mitochondrial electron flow enhances tumor immunogenicity. (2023) Science. 381(6664):1316-1323. DOI: 10.1126/science.abq1053

McDonald, B., Chick, B.Y., Ahmed, N.S., Burns, M., Ma, S., Casillas, E., Chen, D., Mann, T.H., O’Connor, C., Hah, N., Hargreaves, D.C., Kaech, S.M. Canonical BAF complex activity shapes the enhancer landscape that licenses CD8 T cell effector and memory fates. (2023) Immunity. 56(6):1303-1319.e5. DOI: 10.1016/j.immuni.2023.05.005

Ferguson, L.P., Gatchalian, J., McDermott, M.L., Nakamura, M., Chambers, K., Rajbhandari, N., Lytle, N.K., Rosenthal, S.B., Hamilton, M., Albini, S., Wartenberg, M., Zlobec, I., Galván, J.A., Karamitopoulou, E., Vavinskaya, V., Wascher, A., Lowy, A.M., Schürch, C.M., Puri, P.L., Bruneau, B.G., Hargreaves, D.C., Reya, T. Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. (2023) Nature Communications. 14(1):292. DOI: 10.1038/s41467-023-35796-7

Chick, B.Y., Hargreaves, D.C. Switching under selection: how CoREST controls endocrine therapy resistance in ER breast cancer. (2022) Nature Structural & Molecular Biology. DOI: 10.1038/s41594-022-00858-9

Hishida, T., Yamamoto, M., Hishida-Nozaki, Y., Shao, C., Huang, L., Wang, C., Shojima, K., Xue, Y., Hang, Y., Shokhirev, M., Memczak, S., Sahu, S.K., Hatanaka, F., Ros, R.R., Maxwell, M.B., Chavez, J., Shao, Y., Liao, H.K., Martinez-Redondo, P., Guillen-Guillen, I., Hernandez-Benitez, R., Esteban, C.R., Qu, J., Holmes, M.C., Yi, F., Hickey, R.D., Garcia, P.G., Delicado, E.N., Castells, A., Campistol, J.M., Yu, Y., Hargreaves, D.C., Asai, A., Reddy, P., Liu, G.H., Izpisua Belmonte, J.C. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. (2022) Cell Reports. 39(4):110730. DOI: 10.1016/j.celrep.2022.110730

McRae, H.M., Hargreaves, D.C. Old macrophages lose their (circadian) rhythm. (2022) Trends in Immunology. DOI: 10.1016/j.it.2022.02.005

Ahmed, N.S., Gatchalian, J., Ho, J., Burns, M.J., Hah, N., Wei, Z., Downes, M., Evans, R.M., Hargreaves, D.C. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(1). DOI: 10.1073/pnas.2110812119

Maxwell, M.B., Hargreaves, D.C. Down, but Not Out: A Role for SMARCB1 in Synovial Sarcoma. (2021) Cancer Discovery. 11(10):2375-2377. DOI: 10.1158/2159-8290.CD-21-0591

Wang, L., Oh, T.G., Magida, J., Estepa, G., Obayomi, S.M.B., Chong, L.W., Gatchalian, J., Yu, R.T., Atkins, A.R., Hargreaves, D., Downes, M., Wei, Z., Evans, R.M. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(35). DOI: 10.1073/pnas.2109517118

Hargreaves, D.C. Chromatin openness requires continuous SWI/SNF activity. (2021) Nature Genetics. DOI: 10.1038/s41588-021-00781-7

Liao, J., Hargreaves, D.C. The alternative macrophage relay: STAT6 passes the baton to EGR2. (2020) Genes & Development. 34(21-22):1407-1409. DOI: 10.1101/gad.345140.120

Loo, C.S., Gatchalian, J., Liang, Y., Leblanc, M., Xie, M., Ho, J., Venkatraghavan, B., Hargreaves, D.C., Zheng, Y. A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. (2020) Immunity. DOI: 10.1016/j.immuni.2020.06.011

Cortez, J.T., Montauti, E., Shifrut, E., Gatchalian, J., Zhang, Y., Shaked, O., Xu, Y., Roth, T.L., Simeonov, D.R., Zhang, Y., Chen, S., Li, Z., Woo, J.M., Ho, J., Vogel, I.A., Prator, G.Y., Zhang, B., Lee, Y., Sun, Z., Ifergan, I., Van Gool, F., Hargreaves, D.C., Bluestone, J.A., Marson, A., Fang, D. CRISPR screen in regulatory T cells reveals modulators of Foxp3. (2020) Nature. DOI: 10.1038/s41586-020-2246-4

Gatchalian, J., Liao, J., Maxwell, M.B., Hargreaves, D.C. Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes. (2020) Trends in Immunology. DOI: 10.1016/j.it.2019.12.002

Gao, F., Elliott, N.J., Ho, J., Sharp, A., Shokhirev, M.N., Hargreaves, D.C. Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. (2019) Molecular Cell. 75(5):891-904. DOI: 10.1016/j.molcel.2019.06.024

Hargreaves, D.C. Tuning the chromatin landscape of embryonic stem cells. (2019) Stem Cell Investigation. 6:16. DOI: 10.21037/sci.2019.06.02

Gatchalian, J., Malik, S., Ho, J., Lee, D.S., Kelso, T.W.R., Shokhirev, M.N., Dixon, J.R., Hargreaves, D.C. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. (2018) Nature Communications. 9(1):5139. DOI: 10.1038/s41467-018-07528-9

Gatchalian, J., Hargreaves, D.C. Racheting Up Repair. (2018) Immunity. 49(4):577-579. DOI: 10.1016/j.immuni.2018.09.012

Marian, C.A., Stoszko, M., Wang, L., Leighty, M.W., de Crignis, E., Maschinot, C.A., Gatchalian, J., Carter, B.C., Chowdhury, B., Hargreaves, D.C., Duvall, J.R., Crabtree, G.R., Mahmoudi, T., Dykhuizen, E.C. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. (2018) Cell Chemical Biology. DOI: 10.1016/j.chembiol.2018.08.004

Kelso, T.W.R., Porter, D.K., Amaral, M.L., Shokhirev, M.N., Benner, C., Hargreaves, D.C. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. (2017) Elife. 6. DOI: 10.7554/eLife.30506

Miller, E.L., Hargreaves, D.C., Kadoch, C., Chang, C.Y., Calarco, J.P., Hodges, C., Buenrostro, J.D., Cui, K., Greenleaf, W.J., Zhao, K., Crabtree, G.R. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. (2017) Nature Structural & Molecular Biology. 24(4):344-352. DOI: 10.1038/nsmb.3384

Kadoch, C., Hargreaves, D.C., Hodges, C., Elias, L., Ho, L., Ranish, J., Crabtree, G.R. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013) Nature Genetics. 45(6):592-601. DOI: 10.1038/ng.2628

Dykhuizen, E.C., Hargreaves, D.C., Miller, E.L., Cui, K., Korshunov, A., Kool, M., Pfister, S., Cho, Y.J., Zhao, K., Crabtree, G.R. BAF complexes facilitate decatenation of DNA by topoisomerase IIα. (2013) Nature. 497(7451):624-7. DOI: 10.1038/nature12146

Hargreaves, D.C., Crabtree, G.R. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. (2011) Cell Research. 21(3):396-420. DOI: 10.1038/cr.2011.32

Hargreaves, D.C., Horng, T., Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. (2009) Cell. 138(1):129-45. DOI: 10.1016/j.cell.2009.05.047

Foster, S.L., Hargreaves, D.C., Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modifications. (2007) Nature. 447(7147):972-8. DOI: 10.1038/nature05836

Hargreaves, D.C., Medzhitov, R. Innate sensors of microbial infection. (2005) J. Clin. Immunol. 25(6):503-10. DOI: 10.1007/s10875-005-8065-4

Luther, S.A., Bidgol, A., Hargreaves, D.C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J.G. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (2002) Journal of immunology. 169(1):424-33.

Cyster, J.G., Ansel, K.M., Ngo, V.N., Hargreaves, D.C., Lu, T.T. Traffic patterns of B cells and plasma cells. (2002) Advances in Experimental Medicine and Biology. 512:35-41.

Hargreaves, D.C., Hyman, P.L., Lu, T.T., Ngo, V.N., Bidgol, A., Suzuki, G., Zou, Y.R., Littman, D.R., Cyster, J.G. A coordinated change in chemokine responsiveness guides plasma cell movements. (2001) Journal of Experimental Medicine. 194(1):45-56.