Principal Investigator

Diana Hargreaves
Principal Investigator
Diana received her Bachelor of Science from Haverford College and subsequently worked with Dr. Jason Cyster at the University of California, San Francisco. She completed her doctoral training in the Yale Immunobiology Department with Dr. Ruslan Medzhitov under an NSF Graduate Fellowship where she studied epigenetic and transcriptional mechanisms regulating immune response genes. She went on to focus on the SWI/SNF complex in her postdoctoral studies at Stanford University under Dr. Gerald Crabtree. During that time, she was the recipient of the Helen Hay Whitney Foundation Postdoctoral Fellowship, the Ann Schreiber Research Training Program of Excellence Award, and the K99/R00 Pathway to Independence Award. She joined the Salk Institute as an Assistant Professor in the Molecular and Cell Biology Laboratory in 2015, was promoted to Associate Professor in 2021, and Professor in 2025. She holds the Kieckhefer Foundation Chair. She is the recipient of the American Cancer Society Research Scholar Award, the Pew-Stewart Scholar for Cancer Research Award, as well as the V Foundation Scholar and All-Star Awards.
Research Associates

Nasiha Ahmed
Research Associate
Salk Cancer Center T32 Postdoctoral Fellow
Nasiha received her BA majoring in biology and anthropology from St. Olaf College in Minnesota. She completed her PhD from the University of Arizona in the lab of Dr. Jacob Schwartz, where she studied the role of intrinsically disordered proteins in the pediatric cancer Ewing sarcoma. She joined the Hargreaves lab in September 2020 and her work focuses on the ncBAF complex in macrophage activation. Outside of the lab, Nasiha enjoys creative writing and exploring the San Diego food scene.

Helen McRae
Research Associate
Salk Postdoctoral Fellow
Tang Prize Awardee
CRI Irvington Postdoctoral Fellow
Helen received her B.Sc (Hons) majoring in genetics from the University of Melbourne in Australia. She completed her PhD through the Walter and Eliza Hall Institute of Medical Research in Melbourne Australia in the laboratory of Anne Voss and Tim Thomas where she studied the in vivo role of PHF6 in haematopoietic development and leukaemia. Helen joined the Hargreaves lab in September 2019 and is investigating the role of BAF complex subunits in the tumour microenvironment. Outside of the lab, some of Helen’s favourite activities include running, karaoke and swimming in the ocean.
Research Assistants

Visiting Researcher
Graduate Students

Brent Chick
Graduate Student
UCSD T32 Pathways in Biological Science (PiBS) Predoctoral Trainee
Mary K. Chapman Foundation Awardee

Shitian (Steven) Li
Graduate Student
Steven, a native of Hunan province in central China, relocated to the United States in 2016 to pursue higher education. He graduated from the University of California, San Diego (UCSD) with Cum Laude honors, holding double majors in Bioengineering and Mathematics. During his undergraduate time, Steven worked with Dr. Yingxiao (Peter) Wang to develop FRET-based histone H3 acetylation biosensors, and conducted senior design research with Dr. Stephanie Fraley to develop automated z-stack image analysis software for the analysis of 3D collagen gels. Following his graduation, he joined Dr. Crystal Zhao at Sanford Burnham Prebys Medical Discovery Institute, to investigate RNA m6A modifications. In 2021, he returned to UCSD/Salk to pursue a PhD in Biological Sciences and in May 2022 joined the Hargreaves lab. He is currently conducting research on the role of BAF complex in cytosolic ssDNA release and sensing. In his spare time, he enjoys cooking, listening to music, and indulging in wine and beer tasting.

Hannah Rattu Mandias
Graduate Student
UCSD T32 Predoctoral trainee
NIH F31 Predoctoral Fellow
During her undergraduate education, Hannah worked in Dr. Brian Livingston’s lab at California State University Long Beach (CSULB), where she studied sea urchin embryos as model organisms for biomineralization. She became interested in studying epigenetic regulation through UC Berkeley’s summer research program. There, she worked in Dr. Lin He’s lab studying the role of EZH2, the catalytic subunit of PRC2, in metastatic lung adenocarcinoma. Hannah graduated from California State University Long Beach with departmental honors and a Bachelor’s of Science in General Biology in 2020. Currently, Hannah is a 2nd year PhD student in UC San Diego’s Biological Sciences program and works at the Hargreaves lab at the Salk Institute, where she is studying the involvement of PBRM1 in alveolar macrophage development and function. In her free time, Hannah enjoys going to the gym, painting, and spending time with her dog.


Samuel Rivera
Graduate Student
Sam completed his B.S. in Biology at Boston College, where he studied cyclase signaling in Charles Hoffman’s lab. After graduation, Sam joined Mike Greenberg’s lab at Harvard Medical School as a research assistant, there he studied microglia-neuron interactions in experience-dependent synaptic refinement during development. Sam received an M.S. in Biotechnology from Northeastern University, where he became excited about immune-targeted cancer therapies. Driven by this interest he performed research in discovery groups at Takeda Oncology, on an iPSC-derived CAR-T program, and Oncorus, developing an oncolytic virus platform. Sam joined the Biological Sciences program at UCSD in 2021, and the Hargreaves Lab in 2022. Sam is interested in characterizing the effect of BAF complex mutations in tumors on infiltrating immune cell behavior, particularly in the context of immune-targeted therapies. Outside of the lab Sam likes to play soccer, ride his bike and go to the beach.
Student Trainee
